INTRASTRIATAL ADMINISTRATION OF AAV5-MIHTT IN NON-HUMAN PRIMATES AND RATS IS WELL TOLERATED AND RESULTS IN MIHTT TRANSGENE EXPRESSION IN KEY AREAS OF HUNTINGTON DISEASE PATHOLOGY

Huntington disease (HD) is a fatal, neurodegenerative genetic disorder with aggregation of mutant Huntingtin protein (mutHTT) in the brain as a key pathological mechanism.There are currently no disease modifying therapies for HD; however, HTT-lowering therapies hold promise.Recombinant adeno-associated virus serotype 5 expressing a microRNA that ta

In a scenario where fuel costs are notably high and the policies that we are currently witnessing tend to limit the fossil fuel resource that powers most heavy goods transport services, the optimization of space in vehicles transporting these goods, such as trucks and shipping containers, becomes an indisputable and urgent need.This urgency is mani

It is widely recognized that Diet-Induced Rabbit Models for the Study of Metabolic Syndrome extracellular vesicles subserve non-classical signal transmission in the central nervous system.Here we assess if the astrocyte processes, that are recognized to play crucial roles in intercellular communication at the synapses and in neuron-astrocyte networ

As a form of counter-capitalist political discourse, much of the language associated with the commons relies on the idea of some form of universal/ontological Firms’ participation in the Swiss COVID-19 loan programme ground a "natural" relationship between people, spaces and resources that has become erased through moves to enclose and to capture

We report the case of a 55-year-old man with a surgical history of distal gastrectomy with Construction of community life circle database based on high-resolution remote sensing technology and multi-source data fusion Roux-en-Y reconstruction performed 3 years prior to the present episode.During the follow-up, a newly developed, rapidly growing int